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ANDzymeTM


                  
    

Our proprietary platform ANDzymeTM synchronously performs three functions: target recognition, transduction, and signal generation. It is engineered as a real-time fluorescent sensor to target a wide-range of pathogenic bacteria that have implications in water quality, food safety, and medical diagnoses. We isolate ANDzymeTM molecules using our patented approach to in vitro selection. We have shown that this method is effective for creating sensors that are highly specific and we continuously strive to expand ANDzyme's repertoire of targets. Our mission is to design sensors that are efficient, easy-to-use and cost-effective. ANDzymeTM is the first step toward this goal. 

                  




Features and Benefits 



 

       

   

     

Rapid Assay Time

Minimal sample processing and a "mix-and-read" type assay significantly decrease the time-to-result





 

Thermal Stability

By The inherent stability of DNA allows for longer shelf life and reduces sensor malfunction rates
 



  Cost-effective Manufacturing

Modern chemical synthesis of oligonucleotides have made production of ANDzymeTM extremely affordable


Examples of Target Pathogens



                    

    

Escherichia coli

E. coli has evoked both fear and concern for how we manage water quality. The presence of E. coli in drinking and recreational water is an indicator for the presence of fecal contamination and possibly other dangerous pathogens.

                  

   

 
Salmonella typhimurium

S. typhimurium is culprit for one of the most common enteric infections in North America. Incidence of food-borne infections caused by Salmonella is on the rise. Common sources of Salmonella are raw eggs, undercooked poultry, and certain vegetables.

 
   

 
Listeria monocytogenes 

What sets L. monocytogenes from other food-borne pathogens is its ability to multiply and thrive at refrigerated temperatures. In particular, packaged deli meats, soft cheeses and certain fruits are often vulnerable to contamination.

 
   

 
Clostridium difficile 

C. diff is a major concern for hospitals worldwide because their spores are capable of surviving on surfaces for years. This persistence have caused the rate of C. diff infections to double in the last few years in Canada, U.S., and Europe.