In vitro Selection


Over the past 25 years, we have seen a plethora of functional DNA and RNA sequences isolated using a technique often referred to as in vitro selection or SELEX (systematic evolution of ligands by exponential enrichment). We have also seen the evolution of this technique as it strives to accommodate the desire of isolating functional nucleic acid sequences with more complex chemistries. Over the past 15 years, we have developed our own strategies for isolating functional nucleic acid sequences by integrating modern instrumentation and predictive bioinformatic models to isolate functionally rich molecules. See how our technology can help your research and how it differentiates us from our competitors here. 


Multi-round Deep Sequencing 

InnovoGENE Biosciences continues to refine they way Functional Nucleic Acids are isolated. Our research has revealed many key factors that influence successful selection. We have adopted a bioinformatic approach to look deeper into the in vitro selection process. Traditional selection experiments perform sequencing once at the end. This is not enough! We provide for our customers multiple deep sequencing analysis to eliminate variables that can adversely affect your experiment. We have established this unique analytical method by developing an in-house predictive model for identifying highly functional candidates that may otherwise be missed using traditional sequencing. 


The Right Tool for the Right Job


Whether you are looking for an aptamer for small molecules, proteins, or even whole cells, there are many considerations that need to be made before designing an ideal in vitro selection experiment. We do not use one single in vitro selection approach as not all molecular targets are created equal. InnovoGENE Biosciences has developed a proprietary protocol and created a series of in-house methodologies that will best suit your target type and downstream application to ensure we meet your needs. Every in vitro selection project will always begin with an inclusive consultation and evaluation meeting.