Our line of UrasensorsTM were founded on one of the oldest and most well-known sensor - the litmus test. By conjugating urease with oligonucleotides, we can quickly translate various recognition events to modulate a solution's pH. Changes in pH can be easily monitored colourimetrically with pH-dependent dyes. Engineering simple sensors that do not rely on expensive equipment are ideal for rapid screening of many samples. The flexibility of this system allows for a wide adoption of molecular platforms. Learn more about how UrasensorsTM can be utilized in your research here.


A Litmus Test for E. coli in Recreational Waters



E. coli counts in water have been used for many years as an indicator for water quality and safety. Elevated levels of E. coli is often associated with the presence of other toxins and possibly even more dangerous pathogens. Current approaches for monitor E. coli is slow, needing several days before the water sample is assessed, leaving the public exposed to potentially dangerous waters while testing is performed. At InnovoGENE Biosciences, our Urasensor - E. coli detection kit is the first step towards an on-site tests that can be performed within a few hours. This is critical, especially on days with heavy rainfall that causes acute elevation of E. coli from agricultural runoffs and sewage-stormwater overflow that contaminate local waters. Having an immediate response to these situations are key in making informed decisions and providing better health protection.

The E. coli Urasensors rely on the recognition capabilities of the ANDzymeTM system to recognize E. coli with high specificity. Water samples are mixed with our E. coli Urasensors that look for the presence of E. coli. If the pathogen is present, a colour change will be observed from yellow to red. In addition, these results can be interpreted with a smartphone to quantitatively estimate cell counts, while recording other important information such as location, weather, and time.